Active Pharmaceutical Ingredient (API) manufacturing demands a tightly controlled environment, precision-engineered machinery, and integrated operations that span reaction, separation, vacuum drying, and blending. Designed to meet the exacting standards of regulatory agencies like USFDA, EMA, and WHO-GMP, API plants require equipment that ensures closed procesing, inert operation, solvent recovery, and zero cross-contamination.

Integrated Process Equipment Solutions for API Production Plants

1. API Reaction Systems

The foundation of any API plant is its reaction setup, where multi-step chemical synthesis takes place under tightly controlled conditions.

 

a. Stainless Steel Reactor Vessels

• Fabricated from AISI SS316L, suitable for vacuum and pressure conditions.
• Jacketed or limpet coil design for heat transfer.
• Agitators (anchor, turbine, pitched-blade) designed using CFD for optimal mixing.
• Equipped with bottom discharge valves, rupture discs, automated dosing, and nitrogen purging systems.

 

b. Holding & Storage Vessels

• Buffer tanks for intermediates or final APIs.
• Fully drainable, CIP/SIP-ready, with integrated level sensors, sanitary design, and vacuum/pressure safety relief.

 

2. Solid–Liquid Separation Systems

Shiv Shakkti offers multiple technologies for closed, clean, and efficient separation of API slurries post reaction.

1. Basket Centrifuges

 

All models are cGMP compliant, inert gas-sealed, and available in Hastelloy, Inconel, Titanium, Monel, and SS316L:

 

• Manual Top Discharge Basket Centrifuge

• Bottom Discharge Basket Centrifuge

• Bag Lifting Centrifuge

 

All centrifuges feature vacuum compatibility, inert atmosphere sealing, and CIP-friendly basket designs.

b. Agitated Nutsche Filter Dryer (ANFD)

• Multi-stage system for filtration, washing, and drying.
• Also available in exotic alloys.
• Features include jacketed shells, vacuum operation, gas purging, and zero dead-leg discharge.

 

3. Vacuum Drying Systems for API Plants

Drying solutions engineered for complete solvent removal, temperature-sensitive molecules, and crystal integrity preservation.

a. Rotary Vacuum Paddle Dryer (RVPD)

• Horizontal jacketed vessel with hollow shaft agitator.
• Designed for sticky, crystalline, or viscous APIs.
• Cantilever Design allows full isolator integration.

b. Nauta Conical Screw Dryer

• Vertical conical design for gentle drying under vacuum.
• Suitable for heat-sensitive APIs, ensures no retention and complete discharge.

c. Double Cone Vacuum Dryer (RCVD)

• Gentle tumbling, no shear stress.
• Easy cleaning, zero holdup, solvent recovery-ready.

d. Vacuum Tray Dryer (VTD)

• For R&D and pilot batches.
• Features tray-level sensors, vacuum sealing, and automated temperature control.

 

4. Blending & Mixing Systems

Post-drying APIs need uniform blending before final packaging or downstream formulation.

a. Double Cone Blender

• Efficient, low-shear, gravity-based mixing.
• Nearly 100% discharge, suitable for sensitive APIs.

b. Octagonal Blender

• Faceted geometry for cascading motion and fast blending.
• Optional nitrogen purging and sampling ports.

c. Ribbon Blender

• Dual-helical agitators for cohesive or free-flowing powders.
• Optional vacuum operation and liquid spray nozzles.

d. Nauta Conical Screw Mixer

• Gentle yet efficient upward-radial mixing.
• For explosive, toxic, or fragile APIs.

 

5. Pilot & Modular Systems

Shiv Shakkti provides pilot-scale and lab-scale equipment for formulation development, scale-up, and tech transfer:

• Capacities from 10 L to 20,000 L.
• SCADA/PLC-enabled, with vacuum systems and ATEX-rated components.
• Ideal for clinical batch production, process validation, and technology bridging.

 

6. Construction, Compliance & Safety

All equipment is built for pharmaceutical-grade safety, traceability, and compliance:

• Fabricated from SS316L or alloys like Hastelloy C-22, Inconel, Titanium.
• Designed with CIP/SIP systems, drain slopes, and sanitary valves.
• Integrated with ATEX-rated motors, vacuum instrumentation, and batch traceability systems.

 

7. Integrated API Line Architecture

Shiv Shakkti systems are engineered for modular integration across every stage of API production:

Reactor → Centrifuge → Filter-Dryer → Vacuum Dryer → Blender

Each unit is built to:

• Support vacuum transfer and closed-loop operation.
• Minimize manual handling.
• Enable cleanroom compliance and full traceability.

Why Choose Shiv Shakkti?

• 45+ years of API processing expertise.
• 2000+ global installations, including regulated markets.
• Proven excellence in solvent recovery, vacuum drying, and explosion-proof system design.
• Fully modular, scalable, and custom-engineered API lines.

Contact Us for API Plant Solutions

Email: marketing@shivshaktiequipments.com
Website: shivshaktiequipments.com
Call: +91 82919 00674 (Laxmi Vishwakarma, Manager – Exports)